HIV and Ageing - Frailty and HIV

As HIV cohorts age attention is turning to traditional ageing syndromes within people living with HIV. These include issues of multimorbidity, functional difficulties, falls and frailty. Frailty represents a final pathway of multisystem physiological dysfunction, which puts an individual at risk of decompensation when exposed to minor stress events. Those with frailty may be at greatest risk of adverse outcomes within ageing cohorts. Frailty has been demonstrated in PLHIV, with prevalence higher than seen in HIV-negative populations. We investigated frailty in 253 older adults (>50) with HIV in Sussex, UK, demonstrating a prevalence of 19%. Frailty was predicted by traditional rather than HIV factors. Frailty will be discussed in those with HIV in the context of these findings.